A study of bone regeneration effect according to the two different graft bone materials in the cranial defects of rabbits
송현종, 김현우, Min Gwi-Hyeon, 이원표, 유상준, 김병옥,
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송현종 ( Song Hyun-Jong ) - Suncheon Hankook Hospital Department of Dentistry
김현우 ( Kim Hyun-Woo ) - Chosun University School of Dentistry Department of Periodontology
( Min Gwi-Hyeon ) - Chosun University School of Dentistry Department of Periodontology
이원표 ( Lee Won-Pyo ) - Chosun University School of Dentistry Department of Periodontology
유상준 ( Yu Sang-Joun ) - Chosun University School of Dentistry Department of Periodontology
김병옥 ( Kim Byung-Ock ) - Chosun University School of Dentistry Department of Periodontology
Abstract
Guided tissue regeneration (GBR) has been used to promote new bone formation in alveolar bone reconstruction at defective bonesites following tooth loss. Bone grafts used in GBR can be categorized into autogenous, xenogenous, and synthetic bones, and humanallografts depending on the origin. The purpose of this study was to compare the rates of bone regeneration using two different bonegrafts in the cranial defects of rabbits. Ten New Zealand rabbits were used in this study. Four defects were created in each surgical site. Each defect was filled as follows: with nothing, using a 50% xenograft and 50% human freeze-dried bone allograft (FDBA) dependingon the volume rate, human FDBA alone, and xenograft alone. After 4 to 8 weeks of healing, histological and histomorphometricanalyses were carried out. At 4 weeks, new bone formation occurred as follows: 18.3% in the control group, 6.5% in group I, 8.8% ingroup II, and 4.2% in group III. At 8 weeks, the new bone formation was 14.9% in the control group, 36.7% in group I, 39.2% in groupII, and 16.8% in group III. The results of this study suggest that the higher the proportion of human FDBA in GBR, the greater was theamount of clinically useful new bone generated. The results confirm the need for adequate healing period to ensure successful GBRwith bone grafting.
키워드
Allografts; Bone substitutes; Guided tissue regeneration; Heterografts
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